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The Anti-Rheumatic Drug, Leflunomide, Induces Nephrotoxicity in Mice via Upregulation of TGFβ-Mediated p53/Smad2/3 Signaling

Recent studies indicated renal toxicity and interstitial nephritis in patients receiving leflunomide (LEFN), but the exact mechanism is still unknown. The transforming growth factor β (TGFβ)/p53/Smad2/3 pathway crucially mediates renal fibrosis. We aimed to assess the nephrotoxic effect of LEFN in m...

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Detalles Bibliográficos
Autores principales:	Aljohani, Alhanouf A., Alqarni, Yasmeen S., Alrashidi, Maram N., Aljuhani, Maha H., Shehata, Shaimaa A., El-Kherbetawy, Mohamed K., Prabahar, Kousalya, Alshaman, Reem, Alattar, Abdullah, Helaly, Ahmed M. N., Ateyya, Hayam, Ismail, Ezzat A., Zaitone, Sawsan A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9144816/ https://www.ncbi.nlm.nih.gov/pubmed/35622687 http://dx.doi.org/10.3390/toxics10050274

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