Histone Deacetylase Inhibitory Activity and Antiproliferative Potential of New [6]-Shogaol Derivatives

Twenty newly synthesized derivatives of [6]-shogaol (4) were tested for inhibitory activity against histone deacetylases. All derivatives showed moderate to good histone deacetylase inhibition at 100 µM with a slightly lower potency than the lead compound. Most potent inhibitors among the derivative...

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Detalles Bibliográficos
Autores principales: Phaosiri, Chanokbhorn, Yenjai, Chavi, Senawong, Thanaset, Senawong, Gulsiri, Saenglee, Somprasong, Somsakeesit, La-or, Kumboonma, Pakit
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9144829/
https://www.ncbi.nlm.nih.gov/pubmed/35630809
http://dx.doi.org/10.3390/molecules27103332

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9144829/
https://www.ncbi.nlm.nih.gov/pubmed/35630809
http://dx.doi.org/10.3390/molecules27103332

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