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Histone Deacetylase Inhibitory Activity and Antiproliferative Potential of New [6]-Shogaol Derivatives

Twenty newly synthesized derivatives of [6]-shogaol (4) were tested for inhibitory activity against histone deacetylases. All derivatives showed moderate to good histone deacetylase inhibition at 100 µM with a slightly lower potency than the lead compound. Most potent inhibitors among the derivative...

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Detalles Bibliográficos
Autores principales:	Phaosiri, Chanokbhorn, Yenjai, Chavi, Senawong, Thanaset, Senawong, Gulsiri, Saenglee, Somprasong, Somsakeesit, La-or, Kumboonma, Pakit
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9144829/ https://www.ncbi.nlm.nih.gov/pubmed/35630809 http://dx.doi.org/10.3390/molecules27103332

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