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Structural Modeling of TRPA1 Ion Channel—Determination of the Binding Site for Antagonists

TRPA1 is a transmembrane cation channel, one of the most promising targets in the context of respiratory diseases. Its general structure has already been experimentally resolved, but the binding site of TRPA1 antagonists such as HC-030031, a model methylxanthine derivative, remains unknown. The pres...

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Detalles Bibliográficos
Autores principales:	Gawalska, Alicja, Kołaczkowski, Marcin, Bucki, Adam
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9145427/ https://www.ncbi.nlm.nih.gov/pubmed/35630553 http://dx.doi.org/10.3390/molecules27103077

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