Novel Soloxolone Amides as Potent Anti-Glioblastoma Candidates: Design, Synthesis, In Silico Analysis and Biological Activities In Vitro and In Vivo

The modification of natural or semisynthetic triterpenoids with amines can be explored as a promising strategy for improving their pharmacological properties. Here, we report the design and synthesis of 11 novel amide derivatives of soloxolone methyl (SM), a cyano enone-bearing derivative of 18βH-gl...

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Detalles Bibliográficos
Autores principales: Markov, Andrey V., Ilyina, Anna A., Salomatina, Oksana V., Sen’kova, Aleksandra V., Okhina, Alina A., Rogachev, Artem D., Salakhutdinov, Nariman F., Zenkova, Marina A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9145754/
https://www.ncbi.nlm.nih.gov/pubmed/35631429
http://dx.doi.org/10.3390/ph15050603

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9145754/
https://www.ncbi.nlm.nih.gov/pubmed/35631429
http://dx.doi.org/10.3390/ph15050603

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