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Paracrine Interaction of Cholangiocellular Carcinoma with Cancer-Associated Fibroblasts and Schwann Cells Impact Cell Migration

Although the Mitogen-activated protein kinase (MAPK) pathway is enriched in cholangiocarcinoma (CCA), treatment with the multityrosine kinase-inhibitor Sorafenib is disappointing. While cancer-associated fibroblasts (CAF) are known to contribute to treatment resistance in CCA, knowledge is lacking f...

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Detalles Bibliográficos
Autores principales: Gundlach, Jan-Paul, Kerber, Jannik, Hendricks, Alexander, Bernsmeier, Alexander, Halske, Christine, Röder, Christian, Becker, Thomas, Röcken, Christoph, Braun, Felix, Sebens, Susanne, Heits, Nils
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9145811/
https://www.ncbi.nlm.nih.gov/pubmed/35628911
http://dx.doi.org/10.3390/jcm11102785