Synthesis of PP2A-Activating PF-543 Derivatives and Investigation of Their Inhibitory Effects on Pancreatic Cancer Cells

Sphingosine kinase (SK) is involved in the growth of cells, including cancer cells. However, which of its two isotypes—SK1 and SK2—is more favorable for cancer growth remains unclear. Although PF-543 strongly and selectively inhibits SK1, its anticancer effect is not high, and the underlying reason...

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Detalles Bibliográficos
Autores principales: Kim, Su Bin, Oh, Yoon Sin, Kim, Kwang Joon, Cho, Sung Woo, Park, Seung Ki, Baek, Dong Jae, Park, Eun-Young
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9145885/
https://www.ncbi.nlm.nih.gov/pubmed/35630821
http://dx.doi.org/10.3390/molecules27103346

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9145885/
https://www.ncbi.nlm.nih.gov/pubmed/35630821
http://dx.doi.org/10.3390/molecules27103346

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