Pan-Lysyl Oxidase Inhibitor PXS-5505 Ameliorates Multiple-Organ Fibrosis by Inhibiting Collagen Crosslinks in Rodent Models of Systemic Sclerosis

Systemic sclerosis (SSc) is characterised by progressive multiple organ fibrosis leading to morbidity and mortality. Lysyl oxidases play a vital role in the cross-linking of collagens and subsequent build-up of fibrosis in the extracellular matrix. As such, their inhibition provides a novel treatmen...

Descripción completa

Detalles Bibliográficos
Autores principales: Yao, Yimin, Findlay, Alison, Stolp, Jessica, Rayner, Benjamin, Ask, Kjetil, Jarolimek, Wolfgang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9146019/
https://www.ncbi.nlm.nih.gov/pubmed/35628342
http://dx.doi.org/10.3390/ijms23105533

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9146019/
https://www.ncbi.nlm.nih.gov/pubmed/35628342
http://dx.doi.org/10.3390/ijms23105533

Ejemplares similares