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Pan-Lysyl Oxidase Inhibitor PXS-5505 Ameliorates Multiple-Organ Fibrosis by Inhibiting Collagen Crosslinks in Rodent Models of Systemic Sclerosis
Systemic sclerosis (SSc) is characterised by progressive multiple organ fibrosis leading to morbidity and mortality. Lysyl oxidases play a vital role in the cross-linking of collagens and subsequent build-up of fibrosis in the extracellular matrix. As such, their inhibition provides a novel treatmen...
Autores principales: | Yao, Yimin, Findlay, Alison, Stolp, Jessica, Rayner, Benjamin, Ask, Kjetil, Jarolimek, Wolfgang |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9146019/ https://www.ncbi.nlm.nih.gov/pubmed/35628342 http://dx.doi.org/10.3390/ijms23105533 |
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