Development of Extended-Release Mini-Tablets Containing Metoprolol Supported by Design of Experiments and Physiologically Based Biopharmaceutics Modeling

The development of extended-release dosage forms with adequate drug release is a challenge for pharmaceutical companies, mainly when the drug presents high solubility, as in Biopharmaceutics Classification System (BCS) class I. This study aimed to develop extended-release mini-tablets containing met...

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Detalles Bibliográficos
Autores principales: Issa, Michele Georges, de Souza, Natalia Vieira, Jou, Bruna Wenyi Chuang, Duque, Marcelo Dutra, Ferraz, Humberto Gomes
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9146084/
https://www.ncbi.nlm.nih.gov/pubmed/35631478
http://dx.doi.org/10.3390/pharmaceutics14050892

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9146084/
https://www.ncbi.nlm.nih.gov/pubmed/35631478
http://dx.doi.org/10.3390/pharmaceutics14050892

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