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Clinical Study of Serum Serotonin as a Screening Marker for Anxiety and Depression in Patients with Type 2 Diabetes

Over time, studies have shown the importance of determining serotonin levels to diagnose somatic and psychiatric disorders. There are theoretical premises and practical ways to achieve a subtle correlation between the existence of comorbid psychiatric disorders and somatic diseases caused by the cha...

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Autores principales: Moroianu, Lavinia-Alexandra, Cecilia, Curis, Ardeleanu, Valeriu, Pantea Stoian, Anca, Cristescu, Vasilica, Barbu, Raisa-Eloise, Moroianu, Marius
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9146121/
https://www.ncbi.nlm.nih.gov/pubmed/35630069
http://dx.doi.org/10.3390/medicina58050652
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author Moroianu, Lavinia-Alexandra
Cecilia, Curis
Ardeleanu, Valeriu
Pantea Stoian, Anca
Cristescu, Vasilica
Barbu, Raisa-Eloise
Moroianu, Marius
author_facet Moroianu, Lavinia-Alexandra
Cecilia, Curis
Ardeleanu, Valeriu
Pantea Stoian, Anca
Cristescu, Vasilica
Barbu, Raisa-Eloise
Moroianu, Marius
author_sort Moroianu, Lavinia-Alexandra
collection PubMed
description Over time, studies have shown the importance of determining serotonin levels to diagnose somatic and psychiatric disorders. There are theoretical premises and practical ways to achieve a subtle correlation between the existence of comorbid psychiatric disorders and somatic diseases caused by the changes observed in serotonin levels. The present study, classified as retrospective and quantitative, provides evidence for determining the serotonin levels in patients with diabetes and anxiety or depression. A total of 48 patients with diabetes type 2 were enrolled in the study. Blood glucose level, glycated haemoglobin, and serum serotonin were noted, and they completed Hamilton A and Beck Depression Inventory questionnaires. We found robust correlations between serum serotonin and blood glucose (Sig. = 0.008), serum serotonin and HbA1c (Sig. = 0.007), serum serotonin and anxiety (Sig. = 0.000), and serum serotonin and depression (Sig. = 0.000). It is also noteworthy that women recorded extreme values higher than men for glycated haemoglobin (95% confidence interval: 6.92–7.79 in women and 6.30–7.23 in men). In conclusion, using serotonin as a marker of the mentioned diseases in clinical practice is of significant utility, considering the benefits in terms of the evolution and prognosis of comorbidities in patients with type 2 diabetes and anxiety and depressive symptoms.
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spelling pubmed-91461212022-05-29 Clinical Study of Serum Serotonin as a Screening Marker for Anxiety and Depression in Patients with Type 2 Diabetes Moroianu, Lavinia-Alexandra Cecilia, Curis Ardeleanu, Valeriu Pantea Stoian, Anca Cristescu, Vasilica Barbu, Raisa-Eloise Moroianu, Marius Medicina (Kaunas) Article Over time, studies have shown the importance of determining serotonin levels to diagnose somatic and psychiatric disorders. There are theoretical premises and practical ways to achieve a subtle correlation between the existence of comorbid psychiatric disorders and somatic diseases caused by the changes observed in serotonin levels. The present study, classified as retrospective and quantitative, provides evidence for determining the serotonin levels in patients with diabetes and anxiety or depression. A total of 48 patients with diabetes type 2 were enrolled in the study. Blood glucose level, glycated haemoglobin, and serum serotonin were noted, and they completed Hamilton A and Beck Depression Inventory questionnaires. We found robust correlations between serum serotonin and blood glucose (Sig. = 0.008), serum serotonin and HbA1c (Sig. = 0.007), serum serotonin and anxiety (Sig. = 0.000), and serum serotonin and depression (Sig. = 0.000). It is also noteworthy that women recorded extreme values higher than men for glycated haemoglobin (95% confidence interval: 6.92–7.79 in women and 6.30–7.23 in men). In conclusion, using serotonin as a marker of the mentioned diseases in clinical practice is of significant utility, considering the benefits in terms of the evolution and prognosis of comorbidities in patients with type 2 diabetes and anxiety and depressive symptoms. MDPI 2022-05-11 /pmc/articles/PMC9146121/ /pubmed/35630069 http://dx.doi.org/10.3390/medicina58050652 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Moroianu, Lavinia-Alexandra
Cecilia, Curis
Ardeleanu, Valeriu
Pantea Stoian, Anca
Cristescu, Vasilica
Barbu, Raisa-Eloise
Moroianu, Marius
Clinical Study of Serum Serotonin as a Screening Marker for Anxiety and Depression in Patients with Type 2 Diabetes
title Clinical Study of Serum Serotonin as a Screening Marker for Anxiety and Depression in Patients with Type 2 Diabetes
title_full Clinical Study of Serum Serotonin as a Screening Marker for Anxiety and Depression in Patients with Type 2 Diabetes
title_fullStr Clinical Study of Serum Serotonin as a Screening Marker for Anxiety and Depression in Patients with Type 2 Diabetes
title_full_unstemmed Clinical Study of Serum Serotonin as a Screening Marker for Anxiety and Depression in Patients with Type 2 Diabetes
title_short Clinical Study of Serum Serotonin as a Screening Marker for Anxiety and Depression in Patients with Type 2 Diabetes
title_sort clinical study of serum serotonin as a screening marker for anxiety and depression in patients with type 2 diabetes
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9146121/
https://www.ncbi.nlm.nih.gov/pubmed/35630069
http://dx.doi.org/10.3390/medicina58050652
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