Cancer Cells Haploinsufficient for ATM Are Sensitized to PARP Inhibitors by MET Inhibition

The MET oncogene encodes a tyrosine kinase (TK) receptor. Its activation protects cells from death but also stimulates DNA damage response by triggering excess replicative stress. Transcriptomic classification of cancer cell lines based on MET expression showed that response to the PARP inhibitor (P...

Descripción completa

Detalles Bibliográficos
Autores principales: D’Ambrosio, Concetta, Erriquez, Jessica, Capellero, Sonia, Cignetto, Simona, Alvaro, Maria, Ciamporcero, Eric, Di Renzo, Maria Flavia, Perera, Timothy, Valabrega, Giorgio, Olivero, Martina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9146142/
https://www.ncbi.nlm.nih.gov/pubmed/35628590
http://dx.doi.org/10.3390/ijms23105770

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9146142/
https://www.ncbi.nlm.nih.gov/pubmed/35628590
http://dx.doi.org/10.3390/ijms23105770

Ejemplares similares