Bioactivity of Novel Pyrazole-Thiazolines Scaffolds against Trypanosoma cruzi: Computational Approaches and 3D Spheroid Model on Drug Discovery for Chagas Disease

Chagas disease, a century-old disease that mainly affects the impoverished population in Latin America, causes high morbidity and mortality in endemic countries. The available drugs, benznidazole (Bz) and nifurtimox, have limited effectiveness and intense side effects. Drug repurposing, and the deve...

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Detalles Bibliográficos
Autores principales: Lara, Leonardo da Silva, Lechuga, Guilherme Curty, Orlando, Lorraine Martins Rocha, Ferreira, Byanca Silva, Souto, Bernardo Araújo, dos Santos, Maurício Silva, Pereira, Mirian Claudia de Souza
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9146228/
https://www.ncbi.nlm.nih.gov/pubmed/35631581
http://dx.doi.org/10.3390/pharmaceutics14050995

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9146228/
https://www.ncbi.nlm.nih.gov/pubmed/35631581
http://dx.doi.org/10.3390/pharmaceutics14050995

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