A Combination of Pharmacophore-Based Virtual Screening, Structure-Based Lead Optimization, and DFT Study for the Identification of S. epidermidis TcaR Inhibitors

The transcriptional regulator (TcaR) enzyme plays an important role in biofilm formation. Prevention of TcaR-DNA complex formation leads to inhibit the biofilm formation is likely to reveal therapeutic ways for the treatment of bacterial infections. To identify the novel ligands for TcaR and to prov...

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Detalles Bibliográficos
Autores principales: Vuppala, Srimai, Kim, Jaeyoung, Joo, Bo-Sun, Choi, Ji-Myung, Jang, Joonkyung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9146354/
https://www.ncbi.nlm.nih.gov/pubmed/35631461
http://dx.doi.org/10.3390/ph15050635

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9146354/
https://www.ncbi.nlm.nih.gov/pubmed/35631461
http://dx.doi.org/10.3390/ph15050635

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