Towards Development of a Non-Toxigenic Clostridioides difficile Oral Spore Vaccine against Toxigenic C. difficile

Clostridioides difficile is an opportunistic gut pathogen which causes severe colitis, leading to significant morbidity and mortality due to its toxins, TcdA and TcdB. Two intra-muscular toxoid vaccines entered Phase III trials and strongly induced toxin-neutralising antibodies systemically but fail...

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Detalles Bibliográficos
Autores principales: Hughes, Jaime, Aston, Carl, Kelly, Michelle L., Griffin, Ruth
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9146386/
https://www.ncbi.nlm.nih.gov/pubmed/35631671
http://dx.doi.org/10.3390/pharmaceutics14051086

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9146386/
https://www.ncbi.nlm.nih.gov/pubmed/35631671
http://dx.doi.org/10.3390/pharmaceutics14051086

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