Discovery of Nitro-azolo[1,5-a]pyrimidines with Anti-Inflammatory and Protective Activity against LPS-Induced Acute Lung Injury

Acute lung injury remains a challenging clinical condition, necessitating the development of novel, safe and efficient treatments. The prevention of macrophage M1-polarization is a viable venue to tackle excessive inflammation. We performed a phenotypic screening campaign to identify azolopyrimidine...

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Detalles Bibliográficos
Autores principales: Spasov, Alexander, Kosolapov, Vadim, Babkov, Denis, Klochkov, Vladlen, Sokolova, Elena, Miroshnikov, Mikhail, Borisov, Alexander, Velikorodnaya, Yulia, Smirnov, Alexey, Savateev, Konstantin, Fedotov, Victor, Kotovskaya, Svetlana, Rusinov, Vladimir
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9146423/
https://www.ncbi.nlm.nih.gov/pubmed/35631365
http://dx.doi.org/10.3390/ph15050537

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9146423/
https://www.ncbi.nlm.nih.gov/pubmed/35631365
http://dx.doi.org/10.3390/ph15050537

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