3,6′- and 1,6′-Dithiopomalidomide Mitigate Ischemic Stroke in Rats and Blunt Inflammation

(1) Background: An important concomitant of stroke is neuroinflammation. Pomalidomide, a clinically available immunomodulatory imide drug (IMiD) used in cancer therapy, lowers TNF-α generation and thus has potent anti-inflammatory actions. Well-tolerated analogs may provide a stroke treatment and al...

Descripción completa

Detalles Bibliográficos
Autores principales: Tsai, Yan-Rou, Kim, Dong Seok, Hsueh, Shih-Chang, Chen, Kai-Yun, Wu, John Chung-Che, Wang, Jia-Yi, Tsou, Yi-Syue, Hwang, Inho, Kim, Yukyung, Gil, Dayeon, Jo, Eui Jung, Han, Baek-Soo, Tweedie, David, Lecca, Daniela, Scerba, Michael T., Selman, Warren R., Hoffer, Barry J., Greig, Nigel H., Chiang, Yung-Hsiao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9146426/
https://www.ncbi.nlm.nih.gov/pubmed/35631536
http://dx.doi.org/10.3390/pharmaceutics14050950

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9146426/
https://www.ncbi.nlm.nih.gov/pubmed/35631536
http://dx.doi.org/10.3390/pharmaceutics14050950

Ejemplares similares