Targeting HIF-1α Function in Cancer through the Chaperone Action of NQO1: Implications of Genetic Diversity of NQO1

HIF-1α is a master regulator of oxygen homeostasis involved in different stages of cancer development. Thus, HIF-1α inhibition represents an interesting target for anti-cancer therapy. It was recently shown that the HIF-1α interaction with NQO1 inhibits proteasomal degradation of the former, thus su...

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Detalles Bibliográficos
Autores principales: Salido, Eduardo, Timson, David J., Betancor-Fernández, Isabel, Palomino-Morales, Rogelio, Anoz-Carbonell, Ernesto, Pacheco-García, Juan Luis, Medina, Milagros, Pey, Angel L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9146583/
https://www.ncbi.nlm.nih.gov/pubmed/35629169
http://dx.doi.org/10.3390/jpm12050747

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9146583/
https://www.ncbi.nlm.nih.gov/pubmed/35629169
http://dx.doi.org/10.3390/jpm12050747

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