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Morphine Accumulates in the Retina Following Chronic Systemic Administration

Opioid transport into the central nervous system is crucial for the analgesic efficacy of opioid drugs. Thus, the pharmacokinetics of opioid analgesics such as morphine have been extensively studied in systemic circulation and the brain. While opioid metabolites are routinely detected in the vitreou...

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Detalles Bibliográficos
Autores principales: Bergum, Nikolas, Berezin, Casey-Tyler, Dooley, Gregory, Vigh, Jozsef
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9146690/
https://www.ncbi.nlm.nih.gov/pubmed/35631353
http://dx.doi.org/10.3390/ph15050527