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The Effect of Dynamic, In Vivo-like Oxaliplatin on HCT116 Spheroids in a Cancer-on-Chip Model Is Representative of the Response in Xenografts
The cancer xenograft model in which human cancer cells are implanted in a mouse is one of the most used preclinical models to test the efficacy of novel cancer drugs. However, the model is imperfect; animal models are ethically burdened, and the imperfect efficacy predictions contribute to high clin...
Autores principales: | Komen, Job, van Neerven, Sanne M., Bossink, Elsbeth G. B. M., de Groot, Nina E., Nijman, Lisanne E., van den Berg, Albert, Vermeulen, Louis, van der Meer, Andries D. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9146796/ https://www.ncbi.nlm.nih.gov/pubmed/35630206 http://dx.doi.org/10.3390/mi13050739 |
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