Uracil as a Zn-Binding Bioisostere of the Allergic Benzenesulfonamide in the Design of Quinoline–Uracil Hybrids as Anticancer Carbonic Anhydrase Inhibitors

A series of quinoline–uracil hybrids (10a–l) has been rationalized and synthesized. The inhibitory activity against hCA isoforms I, II, IX, and XII was explored. Compounds 10a–l demonstrated powerful inhibitory activity against all tested hCA isoforms. Compound 10h displayed the best selectivity pro...

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Detalles Bibliográficos
Autores principales: El-Kalyoubi, Samar A., Taher, Ehab S., Ibrahim, Tarek S., El-Behairy, Mohammed Farrag, Al-Mahmoudy, Amany M. M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9146896/
https://www.ncbi.nlm.nih.gov/pubmed/35631321
http://dx.doi.org/10.3390/ph15050494

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9146896/
https://www.ncbi.nlm.nih.gov/pubmed/35631321
http://dx.doi.org/10.3390/ph15050494

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