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Chromene Derivatives as Selective TERRA G-Quadruplex RNA Binders with Antiproliferative Properties
In mammalian cells, telomerase transcribes telomeres in large G-rich non-coding RNA, known as telomeric repeat-containing RNA (TERRA), which folds into noncanonical nucleic acid secondary structures called G-quadruplexes (G4s). Since TERRA G4 has been shown to be involved in telomere length and tran...
Autores principales: | , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9147070/ https://www.ncbi.nlm.nih.gov/pubmed/35631373 http://dx.doi.org/10.3390/ph15050548 |