Chromene Derivatives as Selective TERRA G-Quadruplex RNA Binders with Antiproliferative Properties

In mammalian cells, telomerase transcribes telomeres in large G-rich non-coding RNA, known as telomeric repeat-containing RNA (TERRA), which folds into noncanonical nucleic acid secondary structures called G-quadruplexes (G4s). Since TERRA G4 has been shown to be involved in telomere length and tran...

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Detalles Bibliográficos
Autores principales: Rocca, Roberta, Scionti, Francesca, Nadai, Matteo, Moraca, Federica, Maruca, Annalisa, Costa, Giosuè, Catalano, Raffaella, Juli, Giada, Di Martino, Maria Teresa, Ortuso, Francesco, Alcaro, Stefano, Tagliaferri, Pierosandro, Tassone, Pierfrancesco, Richter, Sara N., Artese, Anna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9147070/
https://www.ncbi.nlm.nih.gov/pubmed/35631373
http://dx.doi.org/10.3390/ph15050548

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