Preformulation Studies of Ezetimibe-Simvastatin Solid Dispersions in the Development of Fixed-Dose Combinations

Two active pharmaceutical ingredients (APIs) with limited solubility, simvastatin and ezetimibe, prepared as a drug-drug solid dispersion (SD) was evaluated for physicochemical, microstructural, and aqueous dissolution properties. The simvastatin-ezetimibe SD was prepared using the co-grinding metho...

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Detalles Bibliográficos
Autores principales: Górniak, Agata, Złocińska, Adrianna, Trojan, Mateusz, Pęcak, Adrianna, Karolewicz, Bożena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9147300/
https://www.ncbi.nlm.nih.gov/pubmed/35631498
http://dx.doi.org/10.3390/pharmaceutics14050912

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9147300/
https://www.ncbi.nlm.nih.gov/pubmed/35631498
http://dx.doi.org/10.3390/pharmaceutics14050912

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