Cargando…

Preformulation Studies of Ezetimibe-Simvastatin Solid Dispersions in the Development of Fixed-Dose Combinations

Two active pharmaceutical ingredients (APIs) with limited solubility, simvastatin and ezetimibe, prepared as a drug-drug solid dispersion (SD) was evaluated for physicochemical, microstructural, and aqueous dissolution properties. The simvastatin-ezetimibe SD was prepared using the co-grinding metho...

Descripción completa

Detalles Bibliográficos
Autores principales:	Górniak, Agata, Złocińska, Adrianna, Trojan, Mateusz, Pęcak, Adrianna, Karolewicz, Bożena
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9147300/ https://www.ncbi.nlm.nih.gov/pubmed/35631498 http://dx.doi.org/10.3390/pharmaceutics14050912

Ejemplares similares

Screening of Fenofibrate-Simvastatin Solid Dispersions in the Development of Fixed-Dose Formulations for the Treatment of Lipid Disorders
por: Górniak, Agata, et al.
Publicado: (2023)

Efficacy and Tolerability of a Fixed-Dose Combination of Rosuvastatin and Ezetimibe Compared with a Fixed-Dose Combination of Simvastatin and Ezetimibe in Brazilian Patients with Primary Hypercholesterolemia or Mixed Dyslipidemia: A Multicenter, Randomized Trial
por: Vattimo, Antonio Carlos Amedeo, et al.
Publicado: (2020)

Hierarchical Macro-Mesoporous Silica Monolithic Tablets as a Novel Dose–Structure-Dependent Delivery System for the Release of Confined Dexketoprofen
por: Kozakiewicz-Latała, Marta, et al.
Publicado: (2022)

Oral Wound Healing Potential of Polygoni Cuspidati Rhizoma et Radix Decoction—In Vitro Study
por: Hadzik, Jakub, et al.
Publicado: (2023)

Recent Advances in Amorphous Solid Dispersions: Preformulation, Formulation Strategies, Technological Advancements and Characterization
por: Tambe, Srushti, et al.
Publicado: (2022)

Economic evaluation of ezetimibe combined with simvastatin for the treatment of primary hypercholesterolaemia
por: Visseren, F. L. J.
Publicado: (2011)

Physicochemical and Antifungal Properties of Clotrimazole in Combination with High-Molecular Weight Chitosan as a Multifunctional Excipient
por: Grimling, Bożena, et al.
Publicado: (2020)

Complementary Therapy to Target LDL Cholesterol: The Role of the Ezetimibe/Simvastatin Combination
por: Neal, Ryan C, et al.
Publicado: (2006)

Ezetimibe/simvastatin vs simvastatin in coronary heart disease patients with or without diabetes
por: Rotella, Carlo M, et al.
Publicado: (2010)

Comparing Simvastatin Monotherapy V/S Simvastatin-Ezetimibe Combination Therapy for the Treatment of Hyperlipidemia: A Meta-Analysis and Review
por: Chauhan, Dhruva, et al.
Publicado: (2022)

Trends in Ezetimibe Prescriptions as Monotherapy or Fixed-Dose Combination in Germany 2012–2021
por: Katzmann, Julius L., et al.
Publicado: (2022)

Low incidence of paradoxical reductions in HDL-C levels in dyslipidemic patients treated with fenofibrate alone or in combination with ezetimibe or ezetimibe/simvastatin
por: Farnier, Michel, et al.
Publicado: (2011)

Ezetimibe + simvastatin versus doubling the dose of simvastatin in high cardiovascular risk diabetics: a multicenter, randomized trial (the LEAD study)
por: Bardini, Gianluca, et al.
Publicado: (2010)

Pharmacokinetic non-interaction analysis in a fixed-dose formulation in combination of atorvastatin and ezetimibe
por: Patiño-Rodríguez, Omar, et al.
Publicado: (2014)

Preformulation Studies on Piperlongumine
por: Aodah, Alhassan, et al.
Publicado: (2016)

Microemulsion Liquid Chromatographic Method for Simultaneous Determination of Simvastatin and Ezetimibe in Their Combined Dosage Forms
por: Hammouda, Mohammed E. A., et al.
Publicado: (2013)

Rhabdomyolysis after ezetimibe/simvastatin therapy in an HIV-infected patient
por: Chanson, Noemie, et al.
Publicado: (2008)

How Does the Addition of Kollidon(®)VA64 Inhibit the Recrystallization and Improve Ezetimibe Dissolution from Amorphous Solid Dispersions?
por: Szafraniec-Szczęsny, Joanna, et al.
Publicado: (2021)

Molecular Mobility and Stability Studies of Amorphous Imatinib Mesylate
por: Karolewicz, Bożena, et al.
Publicado: (2019)

Evaluation of the Influence of a Hydrogel Containing AMPD on the Stability of Tetracycline Hydrochloride
por: Kostrzębska, Agnieszka, et al.
Publicado: (2021)

Effect of fixed‐dose combinations of ezetimibe plus rosuvastatin in patients with primary hypercholesterolemia: MRS‐ROZE (Multicenter Randomized Study of ROsuvastatin and eZEtimibe)
por: Kim, Kyung‐Jin, et al.
Publicado: (2016)

Management of dyslipidemia and hyperglycemia with a fixed-dose combination of sitagliptin and simvastatin
por: Steinberg, Helmut, et al.
Publicado: (2013)

Stabilisation and Growth of Metastable Form II of Fluconazole in Amorphous Solid Dispersions
por: Nowak, Maciej, et al.
Publicado: (2019)

The Efficacy and Safety of Ezetimibe and Low-Dose Simvastatin as a Primary Treatment for Dyslipidemia in Renal Transplant Recipients
por: Yoon, Hye Eun, et al.
Publicado: (2009)

Physical Stability and Viscoelastic Properties of Co-Amorphous Ezetimibe/Simvastatin System
por: Knapik-Kowalczuk, Justyna, et al.
Publicado: (2019)

Multiparticulate Systems of Ezetimibe Micellar System and Atorvastatin Solid Dispersion Efficacy of Low-Dose Ezetimibe/Atorvastatin on High-Fat Diet-Induced Hyperlipidemia and Hepatic Steatosis in Diabetic Rats
por: Torrado-Salmerón, Carlos, et al.
Publicado: (2021)

Ezetimibe in Combination With Simvastatin Reduces Remnant Cholesterol Without Affecting Biliary Lipid Concentrations in Gallstone Patients
por: Ahmed, Osman, et al.
Publicado: (2018)

Implementing Fixed Dose Combination Medications for the Prevention and Control of Cardiovascular Diseases
por: Webster, Ruth, et al.
Publicado: (2020)

Pectin and Neutral Monosaccharides Production during the Simultaneous Hydrothermal Extraction of Waste Biomass from Refining of Sugar—Optimization with the Use of Doehlert Design
por: Pińkowska, Hanna, et al.
Publicado: (2019)

Effects of Combined Ezetimibe and Simvastatin Therapy as Compared With Simvastatin Alone in Patients With Type 2 Diabetes: A prospective randomized double-blind clinical trial
por: Ruggenenti, Piero, et al.
Publicado: (2010)

Comparative study on solid self-nanoemulsifying drug delivery and solid dispersion system for enhanced solubility and bioavailability of ezetimibe
por: Rashid, Rehmana, et al.
Publicado: (2015)

Reaching target LDL cholesterol has become more affordable with launch of ezetimibe/simvastatin combination in South Africa
Publicado: (2010)

Effect of bempedoic acid plus ezetimibe fixed-dose combination vs ezetimibe or placebo on low-density lipoprotein cholesterol in patients with type 2 diabetes and hypercholesterolemia not treated with statins
por: Bays, Harold E., et al.
Publicado: (2021)

Potential Cardiovascular Events Avoided with Bempedoic Acid Plus Ezetimibe Fixed-Dose Combination Compared with Ezetimibe Alone in Patients with Atherosclerotic Cardiovascular Disease Taking Maximally Tolerated Statins
por: McQueen, R. Brett, et al.
Publicado: (2022)

The Effect of PEG Molecular Weights on Dissolution Behavior of Simvastatin in Solid Dispersions
por: Bolourchian, Noushin, et al.
Publicado: (2013)

Fast disintegrating crystalline solid dispersions of simvastatin for incorporation into orodispersible tablets
por: Pabari, Ritesh M, et al.
Publicado: (2014)

Synergistic effect of simvastatin and ezetimibe on lipid and pro-inflammatory profiles in pre-diabetic subjects
por: Kater, Ana-Lucia A, et al.
Publicado: (2010)

Simvastatin/Ezetimibe Therapy for Recalcitrant Alopecia Areata: An Open Prospective Study of 14 Patients
por: Choi, Joong-Woon, et al.
Publicado: (2017)

Ternary Eutectic Ezetimibe–Simvastatin–Fenofibrate System and the Physical Stability of Its Amorphous Form
por: Knapik-Kowalczuk, Justyna, et al.
Publicado: (2021)

The Bioequivalence and Effect of Food on the Pharmacokinetics of a Fixed‐Dose Combination Tablet Containing Rosuvastatin and Ezetimibe in Healthy Japanese Subjects
por: Nishida, Chisato, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_eoi5qqahi8r75r01ra5emnb3u2