Lack of Major Genome-Wide DNA Methylation Changes in Succinate-Treated Human Epithelial Cells

The tricarboxylic acid (TCA) metabolite, succinate, is a competitive inhibitor of dioxygenase enzymes that require alpha ketoglutarate as a cofactor. One family of dioxygenases are the ten-eleven translocation (TET) proteins, which oxidize 5-methylcytosine to promote DNA demethylation. Inhibition of...

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Detalles Bibliográficos
Autores principales: Cui, Wei, Huang, Zhijun, Pfeifer, Gerd P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9147453/
https://www.ncbi.nlm.nih.gov/pubmed/35628470
http://dx.doi.org/10.3390/ijms23105663

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9147453/
https://www.ncbi.nlm.nih.gov/pubmed/35628470
http://dx.doi.org/10.3390/ijms23105663

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