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Behavior of Regular Insulin in a Parenteral Nutrition Admixture: Validation of an LC/MS-MS Assay and the In Vitro Evaluation of Insulin Glycation

Parenteral-nutrition (PN)-induced hyperglycemia increases morbidity and mortality and must be treated with insulin. Unfortunately, the addition of insulin to a ternary PN admixture leads to a rapid decrease in insulin content. Our study’s objective was to determine the mechanistic basis of insulin’s...

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Detalles Bibliográficos
Autores principales: Henry, Heloise, Goossens, Jean-François, Kouach, Mostafa, Lannoy, Damien, Seguy, David, Dine, Thierry, Odou, Pascal, Foulon, Catherine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9148014/
https://www.ncbi.nlm.nih.gov/pubmed/35631667
http://dx.doi.org/10.3390/pharmaceutics14051081