Design, Cytotoxicity and Antiproliferative Activity of 4-Amino-5-methyl-thieno[2,3-d]pyrimidine-6-carboxylates against MFC-7 and MDA-MB-231 Breast Cancer Cell Lines

Novel 4-amino-thieno[2,3-d]pyrimidine-6-carboxylates substituted at the second position were prepared by cyclocondensation of 2-amino-3-cyano-thiophene and aryl nitriles in an acidic medium. The design of the target compounds was based on structural optimization. The derivatives thus obtained were t...

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Detalles Bibliográficos
Autores principales: Mavrova, Anelia, Dimov, Stephan, Sulikovska, Inna, Yancheva, Denitsa, Iliev, Ivan, Tsoneva, Iana, Staneva, Galya, Nikolova, Biliana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9148072/
https://www.ncbi.nlm.nih.gov/pubmed/35630793
http://dx.doi.org/10.3390/molecules27103314

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9148072/
https://www.ncbi.nlm.nih.gov/pubmed/35630793
http://dx.doi.org/10.3390/molecules27103314

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