PARP inhibitor olaparib enhances the efficacy of radiotherapy on XRCC2-deficient colorectal cancer cells

The use of PARP inhibitors in combination with radiotherapy is a promising strategy to locally enhance DNA damage in tumors. Loss of XRCC2 compromises DNA damage repairs, and induced DNA damage burdens may increase the reliance on PARP-dependent DNA repairs of cancer cells to render cell susceptibil...

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Detalles Bibliográficos
Autores principales: Qin, Changjiang, Ji, Zhiyu, Zhai, Ertao, Xu, Kaiwu, Zhang, Yijie, Li, Quanying, Jing, Hong, Wang, Xiaoliang, Song, Xinming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9148313/
https://www.ncbi.nlm.nih.gov/pubmed/35643812
http://dx.doi.org/10.1038/s41419-022-04967-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9148313/
https://www.ncbi.nlm.nih.gov/pubmed/35643812
http://dx.doi.org/10.1038/s41419-022-04967-7

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