Computational Discovery of Cancer Immunotherapy Targets by Intercellular CRISPR Screens

Cancer immunotherapy targets the interplay between immune and cancer cells. In particular, interactions between cytotoxic T lymphocytes (CTLs) and cancer cells, such as PD-1 (PDCD1) binding PD-L1 (CD274), are crucial for cancer cell clearance. However, immune checkpoint inhibitors targeting these in...

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Detalles Bibliográficos
Autores principales: Yim, Soorin, Hwang, Woochang, Han, Namshik, Lee, Doheon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9149307/
https://www.ncbi.nlm.nih.gov/pubmed/35651625
http://dx.doi.org/10.3389/fimmu.2022.884561

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9149307/
https://www.ncbi.nlm.nih.gov/pubmed/35651625
http://dx.doi.org/10.3389/fimmu.2022.884561

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