Preventing Influenza A Virus Infection by Mixed Inhibition of Neuraminidase and Hemagglutinin by Divalent Inhibitors

[Image: see text] Divalent inhibitors of the neuraminidase enzyme (NA) of the Influenza A virus were synthesized with vastly different spacers. The spacers varied from 14 to 56 atoms and were relatively rigid by way of the building blocks and their connection by CuAAC. As the ligand for these constr...

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Detalles Bibliográficos
Autores principales: Wei, Xuan, Du, Wenjuan, Duca, Margherita, Yu, Guangyun, de Vries, Erik, de Haan, Cornelis A. M., Pieters, Roland J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9150099/
https://www.ncbi.nlm.nih.gov/pubmed/35549211
http://dx.doi.org/10.1021/acs.jmedchem.2c00319

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9150099/
https://www.ncbi.nlm.nih.gov/pubmed/35549211
http://dx.doi.org/10.1021/acs.jmedchem.2c00319

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