Clerodane Diterpenes from Casearia corymbosa as Allosteric GABA(A) Receptor Modulators

[Image: see text] An EtOAc extract of Casearia corymbosa leaves led to an allosteric potentiation of the GABA signal in a fluorometric imaging plate reader (FLIPR) assay on Chinese hamster ovary (CHO) cells stably expressing GABA(A) receptors with an α(1)β(2)γ(2) subunit composition. The activity wa...

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Detalles Bibliográficos
Autores principales: Syafni, Nova, Faleschini, Maria Teresa, Garifulina, Aleksandra, Danton, Ombeline, Gupta, Mahabir P., Hering, Steffen, Hamburger, Matthias
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society and American Society of Pharmacognosy 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9150179/
https://www.ncbi.nlm.nih.gov/pubmed/35475609
http://dx.doi.org/10.1021/acs.jnatprod.1c00840

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9150179/
https://www.ncbi.nlm.nih.gov/pubmed/35475609
http://dx.doi.org/10.1021/acs.jnatprod.1c00840

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