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Single-Molecule Force Spectroscopy Studies of Missense Titin Mutations That Are Likely Causing Cardiomyopathy

[Image: see text] The giant muscle protein titin plays important roles in heart function. Mutations in titin have emerged as a major cause of familial cardiomyopathy. Missense mutations have been identified in cardiomyopathy patients; however, it is challenging to distinguish disease-causing mutatio...

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Detalles Bibliográficos
Autores principales: Zuo, Jiacheng, Zhan, Denghuang, Xia, Jiahao, Li, Hongbin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2021
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9150697/
https://www.ncbi.nlm.nih.gov/pubmed/34618459
http://dx.doi.org/10.1021/acs.langmuir.1c02006