Application of a Physiologically Based Pharmacokinetic Approach to Predict Theophylline Pharmacokinetics Using Virtual Non-Pregnant, Pregnant, Fetal, Breast-Feeding, and Neonatal Populations

Perinatal pharmacology is influenced by a myriad of physiological variables that are changing dynamically. The influence of these covariates has not been assessed systemically. The objective of this work was to use theophylline as a model drug and to predict its pharmacokinetics before, during (incl...

Descripción completa

Detalles Bibliográficos
Autores principales: Abduljalil, Khaled, Gardner, Iain, Jamei, Masoud
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Pediatrics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9150776/
https://www.ncbi.nlm.nih.gov/pubmed/35652056
http://dx.doi.org/10.3389/fped.2022.840710

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9150776/
https://www.ncbi.nlm.nih.gov/pubmed/35652056
http://dx.doi.org/10.3389/fped.2022.840710

Ejemplares similares