Half-Life Extended Nanobody-Based CD38-Specific Bispecific Killercell Engagers Induce Killing of Multiple Myeloma Cells

CD38 is a target for immunotherapy of multiple myeloma. Llama-derived CD38-specific nanobodies allow easy reformatting into mono-, bi- and multispecific proteins. To evaluate the utility of nanobodies for constructing CD38-specific nanobody-based killer cell engagers (nano-BiKEs), we generated half-...

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Detalles Bibliográficos
Autores principales: Hambach, Julia, Fumey, William, Stähler, Tobias, Gebhardt, Anna Josephine, Adam, Gerhard, Weisel, Katja, Koch-Nolte, Friedrich, Bannas, Peter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9150782/
https://www.ncbi.nlm.nih.gov/pubmed/35651607
http://dx.doi.org/10.3389/fimmu.2022.838406

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9150782/
https://www.ncbi.nlm.nih.gov/pubmed/35651607
http://dx.doi.org/10.3389/fimmu.2022.838406

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