Cargando…
Structure of the glucosyltransferase domain of TcdA in complex with RhoA provides insights into substrate recognition
Clostridioides difficile is one of the most common causes of antibiotic-associated diarrhea in developed countries. As key virulence factors of C. difficile, toxin A (TcdA) and toxin B (TcdB) act by glucosylating and inactivating Rho and Ras family small GTPases in host cells, which leads to actin c...
| Autores principales: | , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2022
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9151644/ https://www.ncbi.nlm.nih.gov/pubmed/35637242 http://dx.doi.org/10.1038/s41598-022-12909-8 |