Soluble CD13 induces inflammatory arthritis by activating the bradykinin receptor B1

CD13, an ectoenzyme on myeloid and stromal cells, also circulates as a shed, soluble protein (sCD13) with powerful chemoattractant, angiogenic, and arthritogenic properties, which require engagement of a G protein–coupled receptor (GPCR). Here we identify the GPCR that mediates sCD13 arthritogenic a...

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Detalles Bibliográficos
Autores principales: Tsou, Pei-Suen, Lu, Chenyang, Gurrea-Rubio, Mikel, Muraoka, Sei, Campbell, Phillip L., Wu, Qi, Model, Ellen N., Lind, Matthew E., Vichaikul, Sirapa, Mattichak, Megan N., Brodie, William D., Hervoso, Jonatan L., Ory, Sarah, Amarista, Camila I., Pervez, Rida, Junginger, Lucas, Ali, Mustafa, Hodish, Gal, O’Mara, Morgan M., Ruth, Jeffrey H., Robida, Aaron M., Alt, Andrew J., Zhang, Chengxin, Urquhart, Andrew G., Lawton, Jeffrey N., Chung, Kevin C., Maerz, Tristan, Saunders, Thomas L., Groppi, Vincent E., Fox, David A., Amin, M. Asif
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9151693/
https://www.ncbi.nlm.nih.gov/pubmed/35439173
http://dx.doi.org/10.1172/JCI151827

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9151693/
https://www.ncbi.nlm.nih.gov/pubmed/35439173
http://dx.doi.org/10.1172/JCI151827

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