TGF-β signaling in myeloproliferative neoplasms contributes to myelofibrosis without disrupting the hematopoietic niche

Myeloproliferative neoplasms (MPNs) are associated with significant alterations in the bone marrow microenvironment that include decreased expression of key niche factors and myelofibrosis. Here, we explored the contribution of TGF-β to these alterations by abrogating TGF-β signaling in bone marrow...

Descripción completa

Detalles Bibliográficos
Autores principales: Yao, Juo-Chin, Oetjen, Karolyn A., Wang, Tianjiao, Xu, Haoliang, Abou-Ezzi, Grazia, Krambs, Joseph R., Uttarwar, Salil, Duncavage, Eric J., Link, Daniel C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9151699/
https://www.ncbi.nlm.nih.gov/pubmed/35439167
http://dx.doi.org/10.1172/JCI154092

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9151699/
https://www.ncbi.nlm.nih.gov/pubmed/35439167
http://dx.doi.org/10.1172/JCI154092

Ejemplares similares