Improved in-vivo airway gene transfer via magnetic-guidance, with protocol development informed by synchrotron imaging

Gene vectors to treat cystic fibrosis lung disease should be targeted to the conducting airways, as peripheral lung transduction does not offer therapeutic benefit. Viral transduction efficiency is directly related to the vector residence time. However, delivered fluids such as gene vectors naturall...

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Detalles Bibliográficos
Autores principales: Donnelley, Martin, Cmielewski, Patricia, Morgan, Kaye, Delhove, Juliette, Reyne, Nicole, McCarron, Alexandra, Rout-Pitt, Nathan, Drysdale, Victoria, Carpentieri, Chantelle, Spiers, Kathryn, Takeuchi, Akihisa, Uesugi, Kentaro, Yagi, Naoto, Parsons, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9151774/
https://www.ncbi.nlm.nih.gov/pubmed/35637239
http://dx.doi.org/10.1038/s41598-022-12895-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9151774/
https://www.ncbi.nlm.nih.gov/pubmed/35637239
http://dx.doi.org/10.1038/s41598-022-12895-x

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