GBA1-dependent membrane glucosylceramide reprogramming promotes liver cancer metastasis via activation of the Wnt/β-catenin signalling pathway

The effect of glucosylceramide (GlcCer) reprogramming on liver cancer metastasis remains poorly understood. In this study, we demonstrated that the protein expression of GBA1, which catalyses the conversion of GlcCer to ceramide, was downregulated in liver cancer tissue. A clinical relevance analysi...

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Detalles Bibliográficos
Autores principales: Qiu, Zhidong, Wang, Xuehong, Yang, Zebin, Liao, Sicong, Dong, Wei, Sun, Tian, Wu, Huixian, Zhang, Qinqin, Pan, Zhixiong, Lam, Sin Man, Shui, Guanghou, Jin, Junfei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9151913/
https://www.ncbi.nlm.nih.gov/pubmed/35637196
http://dx.doi.org/10.1038/s41419-022-04968-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9151913/
https://www.ncbi.nlm.nih.gov/pubmed/35637196
http://dx.doi.org/10.1038/s41419-022-04968-6

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