Cargando…

GBA1-dependent membrane glucosylceramide reprogramming promotes liver cancer metastasis via activation of the Wnt/β-catenin signalling pathway

The effect of glucosylceramide (GlcCer) reprogramming on liver cancer metastasis remains poorly understood. In this study, we demonstrated that the protein expression of GBA1, which catalyses the conversion of GlcCer to ceramide, was downregulated in liver cancer tissue. A clinical relevance analysi...

Descripción completa

Detalles Bibliográficos
Autores principales:	Qiu, Zhidong, Wang, Xuehong, Yang, Zebin, Liao, Sicong, Dong, Wei, Sun, Tian, Wu, Huixian, Zhang, Qinqin, Pan, Zhixiong, Lam, Sin Man, Shui, Guanghou, Jin, Junfei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9151913/ https://www.ncbi.nlm.nih.gov/pubmed/35637196 http://dx.doi.org/10.1038/s41419-022-04968-6

Ejemplares similares

Accumulation of Glucosylceramide in the Absence of the Beta-Glucosidase GBA2 Alters Cytoskeletal Dynamics
por: Raju, Diana, et al.
Publicado: (2015)

Preclinical pharmacology of glucosylceramide synthase inhibitor venglustat in a GBA-related synucleinopathy model
por: Viel, Catherine, et al.
Publicado: (2021)

Glucosylceramide in cerebrospinal fluid of patients with GBA-associated and idiopathic Parkinson’s disease enrolled in PPMI
por: Huh, Young Eun, et al.
Publicado: (2021)

S1PR1 induces metabolic reprogramming of ceramide in vascular endothelial cells, affecting hepatocellular carcinoma angiogenesis and progression
por: Wang, Xuehong, et al.
Publicado: (2022)

Metabolomics, a Powerful Tool for Agricultural Research
por: Tian, He, et al.
Publicado: (2016)

Neurological aspects of SARS-CoV-2 infection: lipoproteins and exosomes as Trojan horses
por: Lam, Sin Man, et al.
Publicado: (2022)

Proteomic analysis of small extracellular vesicles from the plasma of patients with hepatocellular carcinoma
por: Dong, Wei, et al.
Publicado: (2022)

Extensive Profiling of Polyphenols from Two Trollius Species Using a Combination of Untargeted and Targeted Approaches
por: Tian, He, et al.
Publicado: (2020)

Rebaudioside A Enhances Resistance to Oxidative Stress and Extends Lifespan and Healthspan in Caenorhabditis elegans
por: Li, Pan, et al.
Publicado: (2021)

Hepatic loss of CerS2 induces cell division defects via a mad2‐mediated pathway
por: Cao, Mingjun, et al.
Publicado: (2022)

Metabolome-Wide Reprogramming Modulated by Wnt/β-Catenin Signaling Pathway
por: Park, Soo Jin, et al.
Publicado: (2023)

Sequestration of polyunsaturated fatty acids in membrane phospholipids of Caenorhabditis elegans dauer larva attenuates eicosanoid biosynthesis for prolonged survival
por: Lam, Sin Man, et al.
Publicado: (2017)

Human CPTP promotes growth and metastasis via sphingolipid metabolite ceramide and PI4KA/AKT signaling in pancreatic cancer cells
por: Zhang, Yanqun, et al.
Publicado: (2022)

SMARCAD1 Promotes Pancreatic Cancer Cell Growth and Metastasis through Wnt/β-catenin-Mediated EMT
por: Liu, Furao, et al.
Publicado: (2019)

Synthesis and Biological Properties of Fungal Glucosylceramide
por: Del Poeta, Maurizio, et al.
Publicado: (2014)

Defining the glucosylceramide population of C. elegans
por: Xatse, Mark A., et al.
Publicado: (2023)

The SPID-GBA study: Sex distribution, Penetrance, Incidence, and Dementia in GBA-PD
por: Straniero, Letizia, et al.
Publicado: (2020)

The Consequences of GBA Deficiency in the Autophagy–Lysosome System in Parkinson’s Disease Associated with GBA
por: Pradas, Eddie, et al.
Publicado: (2023)

Wnt/β-Catenin Signaling as a Driver of Stemness and Metabolic Reprogramming in Hepatocellular Carcinoma
por: Leung, Rainbow Wing Hei, et al.
Publicado: (2022)

Biological relevance of fatty acyl heterogeneity to the neural membrane dynamics of Rhesus macaques during normative aging
por: Lam, Sin Man, et al.
Publicado: (2016)

Plasma lipidomic profiling in murine mutants of Hermansky–Pudlak syndrome reveals differential changes in pro- and anti-atherosclerotic lipids
por: Ma, Jing, et al.
Publicado: (2019)

Ceramides and glucosylceramides are independent antagonists of insulin action
por: Chavez, Jose A, et al.
Publicado: (2012)

Correction: Synthesis and Biological Properties of Fungal Glucosylceramide
por: Del Poeta, Maurizio, et al.
Publicado: (2015)

Wnt and β-Catenin Signaling in the Bone Metastasis of Prostate Cancer
por: Kaplan, Zachary, et al.
Publicado: (2021)

Ubiquitous Transgene Expression of the Glucosylceramide-Synthesizing Enzyme Accelerates Glucosylceramide Accumulation and Storage Cells in a Gaucher Disease Mouse Model
por: Barnes, Sonya, et al.
Publicado: (2014)

The Key Role of the WNT/β-Catenin Pathway in Metabolic Reprogramming in Cancers under Normoxic Conditions
por: Vallée, Alexandre, et al.
Publicado: (2021)

Glucosylceramide synthase upregulates MDR1 expression in the regulation of cancer drug resistance through cSrc and β-catenin signaling
por: Liu, Yong-Yu, et al.
Publicado: (2010)

Glucosylceramide is synthesized at the cytosolic surface of various Golgi subfractions
Publicado: (1992)

Pre- and post-Golgi translocation of glucosylceramide in glycosphingolipid synthesis
por: Halter, David, et al.
Publicado: (2007)

Administration of Glucosylceramide Ameliorated the Memory Impairment in Aged Mice
por: Lee, Yeonju, et al.
Publicado: (2013)

Glucosylceramide synthase maintains influenza virus entry and infection
por: Drews, Kelly, et al.
Publicado: (2020)

AP2/ERF and R2R3-MYB family transcription factors: potential associations between temperature stress and lipid metabolism in Auxenochlorella protothecoides
por: Xing, Guanlan, et al.
Publicado: (2021)

The Wnt/β-Catenin Signaling Pathway Tips the Balance Between Apoptosis and Reprograming of Cell Fusion Hybrids
por: Lluis, Frederic, et al.
Publicado: (2010)

Transient Expression of WNT2 Promotes Somatic Cell Reprogramming by Inducing β-Catenin Nuclear Accumulation
por: Kimura, Mizuki, et al.
Publicado: (2016)

Glucocerebrosidase Mutations and Synucleinopathies. Potential Role of Sterylglucosides and Relevance of Studying Both GBA1 and GBA2 Genes
por: Franco, Rafael, et al.
Publicado: (2018)

Sanguinarine suppresses migration and metastasis in colorectal carcinoma associated with the inversion of EMT through the Wnt/β‐catenin signaling
por: Zhu, Man, et al.
Publicado: (2020)

ARF6 Regulates Neuron Differentiation through Glucosylceramide Synthase
por: Li, Lu, et al.
Publicado: (2013)

Glucosylceramide Administration as a Vaccination Strategy in Mouse Models of Cryptococcosis
por: Mor, Visesato, et al.
Publicado: (2016)

New Insights on Glucosylceramide Synthase in Cancer Drug Resistance and Myelosuppression
por: Gupta, Vineet, et al.
Publicado: (2013)

Transmembrane transporter expression regulated by the glucosylceramide pathway in Cryptococcus neoformans
por: Singh, Arpita, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_3tvp5pn7g1pvd2tnqrljsou6ic