Congenital sideroblastic anemia model due to ALAS2 mutation is susceptible to ferroptosis

X-linked sideroblastic anemia (XLSA), the most common form of congenital sideroblastic anemia, is caused by a germline mutation in the erythroid-specific 5-aminolevulinate synthase (ALAS2) gene. In XLSA, defective heme biosynthesis leads to ring sideroblast formation because of excess mitochondrial...

Descripción completa

Detalles Bibliográficos
Autores principales: Ono, Koya, Fujiwara, Tohru, Saito, Kei, Nishizawa, Hironari, Takahashi, Noriyuki, Suzuki, Chie, Ochi, Tetsuro, Kato, Hiroki, Ishii, Yusho, Onodera, Koichi, Ichikawa, Satoshi, Fukuhara, Noriko, Onishi, Yasushi, Yokoyama, Hisayuki, Yamada, Rie, Nakamura, Yukio, Igarashi, Kazuhiko, Harigae, Hideo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9151922/
https://www.ncbi.nlm.nih.gov/pubmed/35637209
http://dx.doi.org/10.1038/s41598-022-12940-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9151922/
https://www.ncbi.nlm.nih.gov/pubmed/35637209
http://dx.doi.org/10.1038/s41598-022-12940-9

Ejemplares similares