Cargando…

MET∆14 promotes a ligand-dependent, AKT-driven invasive growth

MET is an oncogene encoding the tyrosine kinase receptor for hepatocyte growth factor (HGF). Upon ligand binding, MET activates multiple signal transducers, including PI3K/AKT, STAT3, and MAPK. When mutated or amplified, MET becomes a “driver” for the onset and progression of cancer. The most freque...

Descripción completa

Detalles Bibliográficos
Autores principales:	Cerqua, Marina, Botti, Orsola, Arigoni, Maddalena, Gioelli, Noemi, Serini, Guido, Calogero, Raffaele, Boccaccio, Carla, Comoglio, Paolo M, Altintas, Dogus M
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Life Science Alliance LLC 2022
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9152130/ https://www.ncbi.nlm.nih.gov/pubmed/35636967 http://dx.doi.org/10.26508/lsa.202201409

Ejemplares similares

The PSI Domain of the MET Oncogene Encodes a Functional Disulfide Isomerase Essential for the Maturation of the Receptor Precursor
por: Altintas, Dogus Murat, et al.
Publicado: (2022)

An Observatory for the MET Oncogene: A Guide for Targeted Therapies
por: Altintas, Dogus M., et al.
Publicado: (2023)

An mTOR feedback loop mediates the ‘flare’ (‘rebound’) response to MET tyrosine kinase inhibition
por: Altintas, D. M., et al.
Publicado: (2023)

MET Exon 14 Skipping: A Case Study for the Detection of Genetic Variants in Cancer Driver Genes by Deep Learning
por: Nosi, Vladimir, et al.
Publicado: (2021)

ROR1 is a pseudokinase that is crucial for MET-driven tumorigenesis
por: Lazzari, Luca, et al.
Publicado: (2013)

A receptor-antibody hybrid hampering MET-driven metastatic spread
por: Modica, Chiara, et al.
Publicado: (2021)

Met inhibition revokes IFNγ-induction of PD-1 ligands in MET-amplified tumours
por: Martin, Valentina, et al.
Publicado: (2019)

Distinct retrograde microtubule motor sets drive early and late endosome transport
por: Villari, Giulia, et al.
Publicado: (2020)

Optimizing a Massive Parallel Sequencing Workflow for Quantitative miRNA Expression Analysis
por: Cordero, Francesca, et al.
Publicado: (2012)

Neuropilin 1 and its inhibitory ligand mini-tryptophanyl-tRNA synthetase inversely regulate VE-cadherin turnover and vascular permeability
por: Gioelli, Noemi, et al.
Publicado: (2022)

Activation of the MET receptor attenuates doxorubicin‐induced cardiotoxicity in vivo and in vitro
por: Gallo, Simona, et al.
Publicado: (2020)

SeqBox: RNAseq/ChIPseq reproducible analysis on a consumer game computer
por: Beccuti, Marco, et al.
Publicado: (2018)

Sparsely Connected Autoencoders: A Multi-Purpose Tool for Single Cell omics Analysis
por: Alessandri, Luca, et al.
Publicado: (2021)

MET Oncogene Controls Invasive Growth by Coupling with NMDA Receptor
por: Gallo, Simona, et al.
Publicado: (2022)

The Met oncogene and basal-like breast cancer: another culprit to watch out for?
por: Gastaldi, Stefania, et al.
Publicado: (2010)

MET inhibition overcomes radiation resistance of glioblastoma stem‐like cells
por: De Bacco, Francesca, et al.
Publicado: (2016)

The MET Oncogene as a Therapeutical Target in Cancer Invasive Growth
por: Luraghi, Paolo, et al.
Publicado: (2012)

Reproducible bioinformatics project: a community for reproducible bioinformatics analysis pipelines
por: Kulkarni, Neha, et al.
Publicado: (2018)

Sparsely-connected autoencoder (SCA) for single cell RNAseq data mining
por: Alessandri, Luca, et al.
Publicado: (2021)

Circulating miRNome of Trachemysscripta after elective gonadectomy under general anesthesia
por: Bardi, Edoardo, et al.
Publicado: (2021)

Reviving oncogenic addiction to MET bypassed by BRAF (G469A) mutation
por: Virzì, Anna Rita, et al.
Publicado: (2018)

LPHN2 inhibits vascular permeability by differential control of endothelial cell adhesion
por: Camillo, Chiara, et al.
Publicado: (2021)

HGF and MET: From Brain Development to Neurological Disorders
por: Desole, Claudia, et al.
Publicado: (2021)

A hypoxic signature marks tumors formed by disseminated tumor cells in the BALB-neuT mammary cancer model
por: Msaki, Aichi, et al.
Publicado: (2016)

miRNA profiles of canine cutaneous mast cell tumours with early nodal metastasis and evaluation as potential biomarkers
por: Zamarian, Valentina, et al.
Publicado: (2020)

MET Activation and Physical Dynamics of the Metastatic Process: The Paradigm of Cancers of Unknown Primary Origin
por: Stella, Giulia M., et al.
Publicado: (2017)

MicroRNA 483‐3p overexpression unleashes invasive growth of metastatic colorectal cancer via NDRG1 downregulation and ensuing activation of the ERBB3/AKT axis
por: Candiello, Ermes, et al.
Publicado: (2023)

Efficacy of CAR-T immunotherapy in MET overexpressing tumors not eligible for anti-MET targeted therapy
por: Chiriaco, Cristina, et al.
Publicado: (2022)

MET Inhibitor Capmatinib Radiosensitizes MET Exon 14-Mutated and MET-Amplified Non-Small Cell Lung Cancer
por: Ramesh, Shrey, et al.
Publicado: (2023)

hOA-DN30: a highly effective humanized single-arm MET antibody inducing remission of ‘MET-addicted’ cancers
por: Martinelli, Ilaria, et al.
Publicado: (2022)

A High Affinity Hepatocyte Growth Factor-binding Site in the Immunoglobulin-like Region of Met
por: Basilico, Cristina, et al.
Publicado: (2008)

Correction: hOA-DN30: a highly effective humanized single-arm MET antibody inducing remission of ‘MET-addicted’ cancers
por: Martinelli, Ilaria, et al.
Publicado: (2022)

MET and AKT Genetic Influence on Facial Emotion Perception
por: Lin, Ming-Teng, et al.
Publicado: (2012)

AKT-ions with a TWIST between EMT and MET
por: Tang, Huifang, et al.
Publicado: (2016)

Extracellular Vesicles Mediate Mesenchymal Stromal Cell-Dependent Regulation of B Cell PI3K-AKT Signaling Pathway and Actin Cytoskeleton
por: Adamo, Annalisa, et al.
Publicado: (2019)

Decorin is a novel antagonistic ligand of the Met receptor
por: Goldoni, Silvia, et al.
Publicado: (2009)

MET/HGF Co-Targeting in Pancreatic Cancer: A Tool to Provide Insight into the Tumor/Stroma Crosstalk
por: Modica, Chiara, et al.
Publicado: (2018)

Identification of Altered miRNAs in Cerumen of Dogs Affected by Otitis Externa
por: Lecchi, Cristina, et al.
Publicado: (2020)

PIK3CA hotspot mutations differentially impact responses to MET targeting in MET-driven and non-driven preclinical cancer models
por: Nisa, Lluís, et al.
Publicado: (2017)

Novel insights into Notum and glypicans regulation in colorectal cancer
por: De Robertis, Mariangela, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_7jsdkkk5jip7t9bqo2d4hbmolf