Cargando…

Rare Alleles and Signatures of Selection on the Immunodominant Domains of Pfs230 and Pfs48/45 in Malaria Parasites From Western Kenya

Background: Malaria elimination and eradication efforts can be advanced by including transmission-blocking or reducing vaccines (TBVs) alongside existing interventions. Key transmission-blocking vaccine candidates, such as Pfs230 domain one and Pfs48/45 domain 3, should be genetically stable to avoi...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ochwedo, Kevin O., Ariri, Fredrick O., Otambo, Wilfred O., Magomere, Edwin O., Debrah, Isaiah, Onyango, Shirley A., Orondo, Pauline W., Atieli, Harrysone E., Ogolla, Sidney O., Otieno, Antony C. A., Mukabana, Wolfgang R., Githeko, Andrew K., Lee, Ming-Chieh, Yan, Guiyun, Zhong, Daibin, Kazura, James W.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Genetics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9152164/ https://www.ncbi.nlm.nih.gov/pubmed/35656326 http://dx.doi.org/10.3389/fgene.2022.867906

Ejemplares similares

Signatures of selection and drivers for novel mutation on transmission-blocking vaccine candidate Pfs25 gene in western Kenya
por: Ochwedo, Kevin O., et al.
Publicado: (2022)

Genetic diversity and population structure of the human malaria parasite Plasmodium falciparum surface protein Pfs47 in isolates from the lowlands in Western Kenya
por: Onyango, Shirley A., et al.
Publicado: (2021)

Health care provider practices in diagnosis and treatment of malaria in rural communities in Kisumu County, Kenya
por: Otambo, Wilfred Ouma, et al.
Publicado: (2022)

Hyper-prevalence of submicroscopic Plasmodium falciparum infections in a rural area of western Kenya with declining malaria cases
por: Ochwedo, Kevin O., et al.
Publicado: (2021)

Structure and function of a malaria transmission blocking vaccine targeting Pfs230 and Pfs230-Pfs48/45 proteins
por: Singh, Kavita, et al.
Publicado: (2020)

Larval ecology and bionomics of Anopheles funestus in highland and lowland sites in western Kenya
por: Debrah, Isaiah, et al.
Publicado: (2021)

Clinical malaria incidence and health seeking pattern in geographically heterogeneous landscape of western Kenya
por: Otambo, Wilfred Ouma, et al.
Publicado: (2022)

Genetic Diversity and Population Structure of Anopheles funestus in Western Kenya Based on Mitochondrial DNA Marker COII
por: Debrah, Isaiah, et al.
Publicado: (2023)

Nanobodies against Pfs230 block Plasmodium falciparum transmission
por: Dietrich, Melanie H., et al.
Publicado: (2022)

Preclinical development of a Pfs230-Pfs48/45 chimeric malaria transmission-blocking vaccine
por: Singh, Susheel K., et al.
Publicado: (2021)

The Pfs230 N-terminal fragment, Pfs230D1+: expression and characterization of a potential malaria transmission-blocking vaccine candidate
por: Lee, Shwu-Maan, et al.
Publicado: (2019)

Particle-based, Pfs230 and Pfs25 immunization is effective, but not improved by duplexing at fixed total antigen dose
por: Huang, Wei-Chiao, et al.
Publicado: (2020)

Pfs230 yields higher malaria transmission–blocking vaccine activity than Pfs25 in humans but not mice
por: Healy, Sara A., et al.
Publicado: (2021)

Effects of bacterial composition and aquatic habitat metabolites on malaria vector larval availability in irrigated and non-irrigated sites of Homa Bay county, western Kenya
por: Orondo, Pauline Winnie, et al.
Publicado: (2023)

Asymptomatic and submicroscopic Plasmodium infections in an area before and during integrated vector control in Homa Bay, western Kenya
por: Omondi, Collince J., et al.
Publicado: (2022)

Malaria vector bionomics and transmission in irrigated and non-irrigated sites in western Kenya
por: Ondeto, Benyl M., et al.
Publicado: (2022)

Pfs230 and Pfs48/45 Fusion Proteins Elicit Strong Transmission-Blocking Antibody Responses Against Plasmodium falciparum
por: Singh, Susheel K., et al.
Publicado: (2019)

Preclinical evaluations of Pfs25-EPA and Pfs230D1-EPA in AS01 for a vaccine to reduce malaria transmission
por: Rausch, Kelly M., et al.
Publicado: (2023)

Risk associations of submicroscopic malaria infection in lakeshore, plateau and highland areas of Kisumu County in western Kenya
por: Otambo, Wilfred Ouma, et al.
Publicado: (2022)

Malaria epidemic and transmission foci in highland of Kisii, western Kenya
por: Ochwedo, Kevin O., et al.
Publicado: (2022)

Identification of domains within Pfs230 that elicit transmission blocking antibody responses
por: Tachibana, Mayumi, et al.
Publicado: (2019)

Community case management of malaria in Western Kenya: performance of community health volunteers in active malaria case surveillance
por: Otambo, Wilfred Ouma, et al.
Publicado: (2023)

Insecticide resistance status of Anopheles arabiensis in irrigated and non-irrigated areas in western Kenya
por: Orondo, Pauline Winnie, et al.
Publicado: (2021)

The Dynamics of Naturally Acquired Immune Responses to Plasmodium falciparum Sexual Stage Antigens Pfs230 & Pfs48/45 in a Low Endemic Area in Tanzania
por: Bousema, Teun, et al.
Publicado: (2010)

Expression and purification optimization of an N-terminal Pfs230 transmission-blocking vaccine candidate
por: Lee, Shwu-Maan, et al.
Publicado: (2019)

Effect of predators on Anopheles arabiensis and Anopheles funestus larval survivorship in Homa Bay County Western Kenya
por: Orondo, Pauline Winnie, et al.
Publicado: (2023)

A prospective cohort study of Plasmodium falciparum malaria in three sites of Western Kenya
por: Ondeto, Benyl M., et al.
Publicado: (2022)

Molecular characterization and genotype distribution of thioester-containing protein 1 gene in Anopheles gambiae mosquitoes in western Kenya
por: Onyango, Shirley A., et al.
Publicado: (2022)

Influence of landscape heterogeneity on entomological and parasitological indices of malaria in Kisumu, Western Kenya
por: Otambo, Wilfred Ouma, et al.
Publicado: (2022)

Outer membrane protein complex as a carrier for malaria transmission blocking antigen Pfs230
por: Scaria, Puthupparampil V., et al.
Publicado: (2019)

Antibody responses to two new Lactococcus lactis-produced recombinant Pfs48/45 and Pfs230 proteins increase with age in malaria patients living in the Central Region of Ghana
por: Acquah, Festus K., et al.
Publicado: (2017)

Profiling the Quality and Quantity of Naturally Induced Antibody Responses Against Pfs230 and Pfs48/45 Among Non-Febrile Children Living in Southern Ghana: A Longitudinal Study
por: Broni, Fermin K., et al.
Publicado: (2021)

Malaria diagnosis in rural healthcare facilities and treatment-seeking behavior in malaria endemic settings in western Kenya
por: Omondi, Collince J., et al.
Publicado: (2023)

Antibody response of a particle-inducing, liposome vaccine adjuvant admixed with a Pfs230 fragment
por: Huang, Wei-Chiao, et al.
Publicado: (2020)

Vaccine co-display of CSP and Pfs230 on liposomes targeting two Plasmodium falciparum differentiation stages
por: Huang, Wei-Chiao, et al.
Publicado: (2022)

N-Terminal Pfs230 Domain Produced in Baculovirus as a Biological Active Transmission-Blocking Vaccine Candidate
por: Lee, Shwu-Maan, et al.
Publicado: (2017)

Elucidating functional epitopes within the N-terminal region of malaria transmission blocking vaccine antigen Pfs230
por: Miura, Kazutoyo, et al.
Publicado: (2022)

Dynamics of anti-MSP3 and Pfs230 antibody responses and multiplicity of infection in asymptomatic children from southern Ghana
por: Amoah, Linda E., et al.
Publicado: (2018)

Development and Qualification of an Antigen Integrity Assay for a Plasmodium falciparum Malaria Transmission Blocking Vaccine Candidate, Pfs230
por: Miura, Kazutoyo, et al.
Publicado: (2022)

Increased investment in gametocytes in asymptomatic Plasmodium falciparum infections in the wet season
por: Oduma, Colins O., et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_tpptbu1m4ollaf9u0d9mtpo5cs