Deacetylation of YAP1 Promotes the Resistance to Chemo- and Targeted Therapy in FLT3-ITD(+) AML Cells

The FLT3-ITD mutation occurs in about 30% of acute myeloid leukemia (AML) and is associated with poor prognosis. However, FLT3 inhibitors are only partially effective and prone to acquired resistance. Here, we identified Yes-associated protein 1 (YAP1) as a tumor suppressor in FLT3-ITD(+) AML. YAP1...

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Detalles Bibliográficos
Autores principales: Feng, Panpan, Zhang, Jingru, Zhang, Juan, Liu, Xiaomin, Pan, Lina, Chen, Dawei, Ji, Min, Lu, Fei, Li, Peng, Li, Guosheng, Sun, Tao, Li, Jingxin, Ye, Jingjing, Ji, Chunyan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Cell and Developmental Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9152322/
https://www.ncbi.nlm.nih.gov/pubmed/35656547
http://dx.doi.org/10.3389/fcell.2022.842214

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9152322/
https://www.ncbi.nlm.nih.gov/pubmed/35656547
http://dx.doi.org/10.3389/fcell.2022.842214

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