Either IL-7 activation of JAK-STAT or BEZ inhibition of PI3K-AKT-mTOR pathways dominates the single-cell phosphosignature of ex vivo treated pediatric T-cell acute lymphoblastic leukemia cells

T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive cancer arising from lymphoblasts of T-cell origin. While TALL accounts for only 15% of childhood and 25% of adult ALL, 30% of patients relapse with a poor outcome. Targeted therapy of resistant and high-risk pediatric T-ALL is therefore ur...

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Detalles Bibliográficos
Autores principales: Kuzilková, Daniela, Bugarin, Cristina, Rejlova, Katerina, Schulz, Axel R., Mei, Henrik E., Paganin, Maddalena, Biffi, Alessandra, Biondi, Andrea, Kalina, Tomas, Gaipa, Giuseppe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Fondazione Ferrata Storti 2021
Materias:
ARTICLE - Acute Lymphoblastic Leukemia
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9152963/
https://www.ncbi.nlm.nih.gov/pubmed/34670357
http://dx.doi.org/10.3324/haematol.2021.278796

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9152963/
https://www.ncbi.nlm.nih.gov/pubmed/34670357
http://dx.doi.org/10.3324/haematol.2021.278796

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