Redundant mechanisms driven independently by RUNX1 and GATA2 for hematopoietic development

RUNX1 is essential for the generation of hematopoietic stem cells (HSCs). Runx1-null mouse embryos lack definitive hematopoiesis and die in mid-gestation. However, although zebrafish embryos with a runx1 W84X mutation have defects in early definitive hematopoiesis, some runx1(W84X/W84X) embryos can...

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Detalles Bibliográficos
Autores principales: Bresciani, Erica, Carrington, Blake, Yu, Kai, Kim, Erika M., Zhen, Tao, Guzman, Victoria Sanchez, Broadbridge, Elizabeth, Bishop, Kevin, Kirby, Martha, Harper, Ursula, Wincovitch, Stephen, Dell’Orso, Stefania, Sartorelli, Vittorio, Sood, Raman, Liu, Paul
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Hematology 2021
Materias:
Hematopoiesis and Stem Cells
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9153008/
https://www.ncbi.nlm.nih.gov/pubmed/34492681
http://dx.doi.org/10.1182/bloodadvances.2020003969

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9153008/
https://www.ncbi.nlm.nih.gov/pubmed/34492681
http://dx.doi.org/10.1182/bloodadvances.2020003969

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