Inhibition of NADPH oxidase blocks NETosis and reduces thrombosis in heparin-induced thrombocytopenia

Heparin-induced thrombocytopenia (HIT) is associated with severe and potentially lethal thrombotic complications. NETosis was recently shown to be an important driver of thrombosis in HIT. We investigated the role of reactive oxygen species (ROS) and nicotinamide adenine dinucleotide phosphate (NADP...

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Detalles Bibliográficos
Autores principales: Leung, Halina H. L., Perdomo, Jose, Ahmadi, Zohra, Yan, Feng, McKenzie, Steven E., Chong, Beng H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Hematology 2021
Materias:
Thrombosis and Hemostasis
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9153028/
https://www.ncbi.nlm.nih.gov/pubmed/34478504
http://dx.doi.org/10.1182/bloodadvances.2020003093

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9153028/
https://www.ncbi.nlm.nih.gov/pubmed/34478504
http://dx.doi.org/10.1182/bloodadvances.2020003093

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