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Pentoxifylline alleviates ischemic white matter injury through up-regulating Mertk-mediated myelin clearance

BACKGROUND: Vascular dementia (VAD) is the second most common type of dementia lacking effective treatments. Pentoxifylline (PTX), a nonselective phosphodiesterase inhibitor, displays protective effects in multiple cerebral diseases. In this study, we aimed to investigate the therapeutic effects and...

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Detalles Bibliográficos
Autores principales: Zheng, Lili, Jia, Junqiu, Chen, Yan, Liu, Renyuan, Cao, Runjing, Duan, Manlin, Zhang, Meijuan, Xu, Yun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9153105/
https://www.ncbi.nlm.nih.gov/pubmed/35642056
http://dx.doi.org/10.1186/s12974-022-02480-4