Convergent evolution and multi-wave clonal invasion in H3 K27-altered diffuse midline gliomas treated with a PDGFR inhibitor

The majority of diffuse midline gliomas, H3 K27-altered (DMG-H3 K27-a), are infiltrating pediatric brain tumors that arise in the pons with no effective treatment. To understand how clonal evolution contributes to the tumor’s invasive spread, we performed exome sequencing and SNP array profiling on...

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Detalles Bibliográficos
Autores principales: Arunachalam, Sasi, Szlachta, Karol, Brady, Samuel W., Ma, Xiaotu, Ju, Bensheng, Shaner, Bridget, Mulder, Heather L., Easton, John, Raphael, Benjamin J., Myers, Matthew, Tinkle, Christopher, Allen, Sariah J., Orr, Brent A., Wetmore, Cynthia J., Baker, Suzanne J., Zhang, Jinghui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9153212/
https://www.ncbi.nlm.nih.gov/pubmed/35642016
http://dx.doi.org/10.1186/s40478-022-01381-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9153212/
https://www.ncbi.nlm.nih.gov/pubmed/35642016
http://dx.doi.org/10.1186/s40478-022-01381-0

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